ea0072oc1 | Oral Communications | UKINETS2020
Doornebal Ewald
, Harris Nicola
, Riva Antonio
, Pizanias Michail
, Phillips Sandra
, Zen Yoh
, Sticova Eva
, Prachalias Andreas
, Menon Krishna
, Zamalloa Ane
, Preziosi Melissa
, Heaton Nigel
, Eaton Simon
, Ramage John
, Williams Roger
, Palma Elena
, Srirajaskanthan Rajaventhan
, Chokshi Shilpa
Accumulating evidence suggests that the immunological landscape plays a key role in the progression of neuroendocrine liver metastases (LM-NENs), which is often characterised by immune cell infiltration. Anti-tumour functions of infiltrating lymphocytes are often silenced through hyper-expression of inhibitory checkpoint receptors (CRs) such as PD-1, but favourable outcomes with anti-PD-1 therapy have been low. Recently, functional soluble (cell-free) CRs beyond PD-1 have been...